黄川,教授,博士生导师,重庆英才青年拔尖人才、重庆大学“百人计划”获得者,长期从事于RNA领域的研究。2016年3月毕业于中国科学技术大学,并获理学博士学位。2016年6月起,在美国宾夕法尼亚大学从事博士后研究工作,并于2018年10月入职重庆大学。近年以通讯/一作在Nature structural & molecular biology、Genes & Development、Nucleic Acids Research、Cell Discovery、WIREs RNA、Trends in Biochemical Sciences等国际顶尖学术期刊发表多篇重要论文,他引次数超过3000次。目前担任 Nature Communications、Genes & Development、Cell Reports、WIREs RNA等学术期刊审稿人。
研究方向
转录调控;非编码RNA的生物发生、加工运输、降解通路和生物学功能。
主讲课程
分子生物学、生物化学、细胞生物学
学术兼职
Nature Communications、Genes & Development、Cell Reports、WIREs RNA、Seminars in Cancer Biology、RNA Biology、Oxidative Medicine and Cellular Longevity等期刊审稿人
主要成果
(#corresponding author/通讯作者)
1. Chen X, Zhou M, Yant L, Huang C#. Circular RNA in disease: basic properties and biomedical relevance. Wiley Interdiscip Rev RNA 2022; e1723, online ahead of print.
2. Chen L, Huang C#, Shan G#. Circular RNAs in physiology and non-immunological diseases. Trends Biochem Sci 2022; 47:250-264.
3. You J, Song Z, Lin J, Jia R, Xia F, Li Z, Huang C#. RNAi-directed knockdown induces nascent transcript degradation and premature transcription termination in the nucleus. Cell Discov 2021; 7:79.
4. Jia R, Song Z, Lin J, Li Z, Shan G, Huang C#. Gawky modulates MTF-1-mediated transcription activation and metal discrimination. Nucleic Acids Res 2021; 49:6296-314.
5. Song Z, Jia R, Tang M, Xia F, Xu H, Li Z, Huang C#. Antisense oligonucleotide technology can be used to investigate a circular but not linear RNA-mediated function for its encoded gene locus. Sci China Life Sci 2021; 64:784-94.
6. Song Z, Lin J, Li Z, Huang C#. The nuclear functions of long noncoding RNAs come into focus. Noncoding RNA Res 2021; 6:70-9.
7. Zhou M, Xiao MS, Li Z, Huang C#. New progresses of circular RNA biology: from nuclear export to degradation. RNA Biol 2021; 18:1365-1373.
8. Jia R, Xiao M, Li Z, Shan G, Huang C#. Defining an evolutionarily conserved role of GW182 in circular RNA degradation. Cell Discov 2019; 5:49.
9. Li Z, Kearse GM, Huang C#. The nuclear export of circular RNAs is primarily defined by their length. RNA Biol 2019; 16:1-4.
10. Huang C, Liang D, Tatomer DC, Wilusz JE. A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs. Genes Dev 2018; 32:639-44. (Selected for an Outlook in Genes and Development; Perspectives and Commentary in Science: The long and short of RNA export. Science Vol. 360, No. 6393)
11. Huang C, Wang X, Liu X, Cao S, Shan G. RNAi pathway participates in chromosome segregation in mammalian cells. Cell Discov 2015; 1:15029. (Featured Article in Cell Discovery)
12. Chen L, Huang C, Wang X, Shan G. Circular RNAs in Eukaryotic Cells. Curr Genomics 2015; 16:312-8.
13. Huang C, Shan G. What happens at or after transcription: Insights into circRNA biogenesis and function. Transcription 2015; 6:61-4.
14. Li Z*, Huang C*, Bao C*, Chen L, Lin M, Wang X, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol 2015; 22:256-64. (*co-first author; Research Highlights in Nature Reviews Molecular Cell Biology: Circular RNAs promote transcription, 2015, 16(4); Editors’ Choice in Science: Circular RNA transcriptional circuits, 2015, 347(6228):1327; Featured Article in Nature structural & molecular biology; Most Cited Paper in Nature structural & molecular biology (2015)
15. Dai L, Huang C, Chen L, Shan G, Li ZY. Altered expression of microRNAs in the response to ER stress. Sci Bull 2015; 60:202-9.
获奖情况
中国科学院“朱李月华”奖(2015)
重庆青年拔尖人才(2021)
考沙尔分子遗传学奖(2018提名)
研究生培养
招收对分子生物学、细胞生物学、生物化学、生物信息学等有兴趣的硕士/博士研究生
联系方式
地址:重庆大学,虎溪校区,生命科学学院,办公室504
邮箱:chuanhuang@cqu.edu.cn